不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制研究     

李洁  杨静  赵丽丽 《武汉体育学院学报》2019,53(5):88-94

目的：探讨不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制。方法：将雄性Wistar大鼠50只随机均分为5组：安静对照组（C）、低负荷运动训练组（LT）、中等负荷运动训练组（MT）、高负荷运动训练组（HT）和极高负荷运动训练组（ST），每组10只。各运动组分别进行6周的跑台运动训练。训练方案结束后，取腓肠肌样本，提取线粒体，测定线粒体柠檬酸合成酶（CS）、异柠檬酸脱氢酶（ICD）和α-酮戊二酸脱氢酶（α-KGDHC）活性；线粒体Ga²⁺含量、胞浆NADH、NAD⁺、ATP和ADP含量，以及ICD mRNA转录水平。结果：（1）不同负荷运动训练组线粒体CS、ICD和α-KGDHC的活性均显著高于安静对照组（P < 0.01），且CS和ICD活性由高到低顺序均为：MT组 > HT组 > ST组 > LT组 > C组，α-KGDHC活性由高到低顺序为：HT组 > MT组 > ST组 > LT组 > C组。（2）不同负荷运动训练组线粒体Ca²⁺ 含量均显著高于安静对照组（P < 0.01），其含量由高到低顺序为：MT组 > HT组 > ST组 > LT组 > C组；胞浆NADH/NAD⁺和ATP/ADP的比值均显著低于安静对照组（P < 0.01），其比值由低到高顺序为：MT组 < ST组 < HT组 < LT组 < C组。（3）不同负荷运动训练组ICD mRNA转录水平均高于安静对照组（P < 0.01），其水平由高到低顺序为： MT组 > HT组 > ST组 > LT组 > C组。结论：低负荷、中等负荷、高负荷及极高负荷运动训练均可提高大鼠骨骼肌线粒体三羧酸循环功能，且中等负荷运动训练效果最佳。其机制与胞浆NADH/NAD⁺和ATP/ADP比值、线粒体摄钙能力及限速酶基因的表达有关。  相似文献   

平行/重合D膜超势，Ooguri-Vafa不变量与类型II弦理论/F理论对偶     

蒋笑添  杨富中 《中国科学院大学学报》2019,36(5):590-597

利用类型Ⅱ弦理论/F理论对偶，第一次在平行和重合相区计算一个具体的双D膜系统的超势，并提取Ooguri-Vafa不变量。平行D膜相与重合D膜相间的相变也对应着D膜世界叶上规范理论规范对称性的提升U（1）×…×U（1）→U（n）。计算显示这两个相区的超势截然不同，并给出不同的Ooguri-Vafa不变量。这意味着相变的发生导致两个相区能谱结构的差异。  相似文献   

Examining the influence of grip type on wrist and club head kinematics during the golf swing: Benefits of a local co-ordinate system     

Howie J. Carson  Jim Richards  Bruno Mazuquin 《European Journal of Sport Science》2019,19(3):327-335

Wrist movements have been identified as an important factor in producing a successful golf swing, with their complex motion influencing both club head velocity and orientation. However, a detailed analysis of wrist angles is lacking in the literature. The purpose of this study was to determine kinematics across wrists and club head characteristics during the golf swing under weak, neutral and strong grip conditions. Twelve professional male golfers executed 24 shots using a driver under three grip conditions. A six degrees of freedom analysis of the hand with respect to the distal forearm was performed using a 10-camera three-dimensional motion capture system. Differences in joint angles were explored using repeated measures ANOVAs at key swing events (onset, top of backswing and impact), in addition club head velocity and clubface angle at impact were also explored. Main findings revealed significant differences in flexion/extension and internal/external rotation for both wrists at all swing events, whereas fewer significant interactions were found in ulnar/radial deviation across grips for both wrists at all events. Clubface angle only differed significantly between the weak and the strong and neural grips, presenting a more ‘open’ clubface to the intended hitting direction. This study is the first to explore tri-planar wrist movement and the effect of different grips, such analysis has implications for coaching knowledge and practice and should inform future research into different aspects of skill, technique analysis and may inform injury mechanisms/prevention.  相似文献   

基于Sentinel-1/2的水体提取方法对比研究——以斯里兰卡小型水体为例     

周晗  叶虎平  魏显虎  张宗科  王法溧  齐永菊  马建如 《中国科学院大学学报》2019,36(6):794-802

地表水面精确提取是研究地表水质和水量变化的重要基础。斯里兰卡是"21世纪海上丝绸之路"的重要参与国，年降雨量丰富，但时空分布不均，斯里兰卡人民长期用水困难，研究斯里兰卡地表水体有助于斯里兰卡民生问题的解决。斯里兰卡国内散布着大量的小型水库和坑塘，这些小面积水体易受周边环境因素影响而提取困难。基于2017年7月斯里兰卡中东部地区的哨兵（Sentinel）1/2号卫星影像，对比分析单波段法、水体指数法和监督分类等水体提取方法的精度和存在的问题。结果表明，归一化水体指数法NDWI的准确率最高，分类精度达94%。  相似文献   

Game-Based Learning in Virtual Worlds: A Multiuser Online Game for Medical Undergraduate Radiology Education within Second Life     

Rocio Lorenzo-Alvarez  Teodoro Rudolphi-Solero  Miguel J. Ruiz-Gomez  Francisco Sendra-Portero 《Anatomical sciences education》2020,13(5):602-617

Game-based learning can have a positive impact on medical education, and virtual worlds have great potential for supporting immersive online games. It is necessary to reinforce current medical students' knowledge about radiological anatomy and radiological signs. To meet this need, the objectives of this study were: to design a competition-based game in the virtual world, Second Life and to analyze the students' perceptions of Second Life and the game, as well as to analyze the medium-term retention of knowledge and the potential impact on the final grades. Ninety out of 197 (45.6%) third-year medical students voluntarily participated in an online game based on self-guided presentations and multiple-choice tests over six 6-day stages. Participants and non-participants were invited to perform an evaluation questionnaire about the experience and a post-exposure knowledge test. Participants rated the experience with mean scores equal to or higher than 8.1 on a 10-point scale, highlighting the professor (9.5 ± 1.1; mean ± SD) and the virtual environment (8.9 ± 1.1). Participants had better results in the post-exposure test than non-participants (59.0 ± 13.5 versus 45.3 ± 11.5; P < 0.001) and a lower percentage of answers left blank (6.7 ± 8.4 versus 13.1 ± 12.9; P = 0.014). Competitive game-based learning within Second Life is an effective and well-accepted means of teaching core radiological anatomy and radiological signs content to medical students. The higher medium-term outcomes obtained by participants may indicate effective learning with the game. Additionally, valuable positive perceptions about the game, the educational contents, and the potential benefit for their education were discovered among non-participants.  相似文献   

The impact of student misconceptions on student persistence in a MOOC     

Chen Chen  Gerhard Sonnert  Philip M. Sadler  Dimitar Sasselov  Colin Fredericks 《科学教学研究杂志》2020,57(6):879-910

Massive Online Open Courses (MOOCs) provide opportunities to learn a vast range of subjects. Because MOOCs are open to anyone with computer access and rarely have prerequisite requirements, the range of student backgrounds can be far more varied than in conventional classroom-based courses. Prior studies have shown that misconceptions have a huge impact on students' learning performance; however, no study has empirically examined the relationship between misconceptions and learning persistence. This study of 12,913 MOOC-takers examines how students' misconceptions about the upcoming course material affect course completion. Using a survival analysis approach, we found that, controlling for the score in a pre-course test, students holding more misconceptions had a higher dropout rate at the start of the course, an effect that diminished over time. Other student variables were found to have a positive impact on survival that persisted throughout the entire course: U.S. location, higher age, an intention to complete, better English skills, prior familiarity with the subject, motivation to earn a certificate, and score and time spent on the previous problem set (homework). By contrast, student gender, education level, number of previous MOOCs completed, and motivation to participate in online discussion forums did not affect survival.  相似文献   

Mapping migrant vernacular discourses: Mestiza consciousness,nomad thought,and Latina/o/x migrant movement politics in the United States     

Michael Lechuga 《Journal of International and Intercultural Communication》2020,13(3):257-273

ABSTRACT

This essay reads the Latina/o/x migrant vernacular discourses that emerge out of pro-migrant activism. Anzaldúa’s notion of mestizaje – a logic of border consciousness – is put into conversation with Deleuze’s notion of nomad thought – a logic of movement – to inform a rhetorical strategy for reading the vernacular archive of social movement discourse. The “No Papers, No Fear” is one such social movement that demonstrate the logic of mestizaje/nomadism in their communication strategies. This study illuminates three tensions that define the ways Latina/o/x migrants in the US navigate the spaces of citizenship: tensions between movement/stasis, migrant identity/national identity, and fear/safety.  相似文献   

人文社科专著众筹OA出版发展现状和思考——以Open Book Publishers和Knowledge Unlatched为例     

徐志玮 《图书情报工作》2021,64(22):77-84

[目的/意义] 梳理人文社科专著众筹OA出版的发展现状，分析具有公益性特点的OA出版物和具有商业性特点的众筹出版所引起的冲突，以期对学术专著众筹出版提出有价值的思考。[方法/过程] 从发起者、投资者和众筹平台3个基本要素梳理Open Book Publishers和Knowledge Unlatched的众筹模式，比较异同点，探讨两者在竞争中引起的问题。[结果/结论] 目前，欧美国家的学术专著众筹出版分为高校、众筹商和OA出版社3种模式。Knowledge Unlatched是期望通过对图书馆的优质服务获得收益的众筹商，Open Book Publishers是借助网络开展众筹出版的OA出版社，两者属于商业化大型公司和非营利性OA出版社的竞争关系，在OA出版物的商业化开发、财务公开透明、垄断性的销售模式和审核制度方面值得高度关注。  相似文献   

Teaching for social justice: A research synthesis on Asian American and Pacific Islander teachers in U.S. schools     

《Teaching and Teacher Education》2020

This article examines social justice in teaching and teacher education with a focus on the experiences, pedagogies, and instructional practices of Asian American and Pacific Islander (AAPI) teachers. We synthesized 37 peer-reviewed research publications on AAPI teachers’ experiences and contributions to diversity and social justice. The results show AAPI teachers disrupting Whiteness through beliefs, pedagogies, and practices that value multiple perspectives and marginalized voices. Policy implications include supporting cultural and linguistic diversity in teacher education programs and schools and providing opportunities for teachers to engage in critical praxis regarding their racial identities and issues of equity in education.  相似文献   

Press Credentials and Hybrid Boundary Zones: The Case of WorldNetDaily and the Standing Committee of Correspondents     

Jordan M. Foley 《Journalism Practice》2020,14(8):933-953

ABSTRACT

Press credentialing practices are a vital, yet understudied site of scholarly research on journalistic norms and practices. Press credentialing not only structures internal professional hierarchies, but they also signify the boundaries of the journalistic field itself. This paper explores the legal and theoretical implications of press credentialing to cover the United States Congress, drawing on the concepts of boundary work and journalistic authority to demonstrate the material impact of the space between fields on professional legitimation in journalism. Using WorldNetDaily (WND) as a case study, I argue that the Standing Committee of Correspondents (SCC) occupies a hybrid boundary zone between the journalistic and political fields, generating a unique tension in First Amendment jurisprudence that places journalists in a paradoxical role as both the professional embodiments of free speech and its constitutional steward. The resulting jurisdictional conflict between the SCC and WND extends the relational model of journalistic authority by articulating how journalist-state relations can fundamentally augment the process of legitimation at its fuzzy boundaries. The relevance and implications for press credentialing practices in the digital age are discussed.  相似文献